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As reported by
City am and a host more places, the UK and Scandinavia are reporting a new covid variant called BA.2. It is so infectious, spreading so quickly, that almost 50% of all Danish cases are now BA.2. On 24th January, in the UK, we had more than 400 confirmed BA.2 infections. By now, a week later, the number will be a great deal higher. The new mutation has also turned up in Norway, Sweden, Singapore, and India.
The new variant is being nicknamed ‘Stealth Omicron’ by the media, and it’s quickly pushing its way past omicron to become the mutation of the moment. Like previous variants BA.2 is mostly a mystery right now, simply because it takes science a while to catch up and do the relevant tests.
What do we know about BA.2 so far?
The super-fast rise of BA.2 in Denmark and elsewhere suggests it might beat omicron. The country’s new Covid infections have shot to record highs with more than 30,000 new cases a day last week, ten times more than ever before.
In Norway there have been a few cases where people who caught omicron have subsequently also caught BA.2. One covid expert says it’s ‘remarkable’ how omicron and BA.2 have such significant differences around immunity and infection.
So far BA.2 seems relatively mild. Hospitalisation numbers and death rates seem much the same as omicron but experts warn it’s early days. They haven’t been observing the new variant for long. So far, until we understand more, those in the know say BA.2 should be treated like any other variant.
Apparently vaccines should still work against BA.2. On the other hand one of the reasons its fast spread could be that it’s better at evading people’s immunity, which means it can infect better.
Seriously ill covid patients’ genetics deliver a vital clue
It looks like
a group of genetic variants found in severely ill covid patients might be behind the differences in how poorly people get.
The virus must attach to human cells, get inside them, and multiply. To do this it has to create inflammation. The team at the Medical College of Georgia at Augusta University, USA , has pinned down genes with structural changes in very sick people that affect these vital processes
In nine of the sickest patients the team found seven rare structural variants affecting 31 genes involved in mediating the response between a person and a virus. One, for example, leads to the over-expression of keratin genes. Keratins, found in human hair and nails, are also important for transmitting flu and covid viruses between cells, where they can ‘hyperactivate’ normal bodily systems and lead to severe illness or death.
11 year old boy catches 3 different variants
The
Healthsite reports on an eleven year old Israeli boy who has been infected with three different covid variants over 365 days. He has tested positive for alpha, delta, and now omicron, and has been in quarantine several times. The first two infections were quite nasty, with ‘pretty serious’ symptoms, but omicron hasn’t been so bad.
Moderna’s Omicron vaccine goes to clinical trial
Moderna has started a clinical trial for a booster jab designed specifically for omicron, and the first participant has had their test dose. They’ll be enrolling 600 adults in the trial, half of whom will have received three doses of the original Moderna vaccine, including a booster. The rest will have only had two jabs of the original. Both groups will get the new booster. Pfizer and BioNTech are also testing an omicron-specific jab.
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