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New research shows how covid might enter the brain by stimulating the growth of miniature tunnels leading from the cells in the nose to brain cells, which the virus can travel through. The finding may have clarified a mystery that’s been puzzling scientists since covid first turned up in 2019.
Covid is famous for brain fog and confusion as well as a host of other neurological symptoms. But previous research hinted the ACE2 receptor the virus usually uses to get into human cells is only just detectable in the brain, much less so than the cells in the mouth, nose and lungs. Now a team in France has pinned down a ‘sneaky’ way for the virus to get into the cells that don’t have the ACE2 cells, travelling via ACE2 receptor cells that do.
Using an extremely powerful electron microscope, the virus was spotted entering model nose cells, then stimulating them to grow tiny ‘tunnelling nanotubes’ that connect with brain cells. This means the virus is transferred from one cell to another, bypassing ACE2 receptors. While more studies are needed to confirm the same mechanism happens inside the brain, it’s an eye-opener.
If these tunnelling nanotubes really do transport covid from the nose to the brain, it could be possible to make drugs to block the tunnels. One team is already hunting for specific tunnelling nanotube-blocking molecules.
Can you do anything to avoid covid BA.4 and .5 variants?
All covid variants pose risk of serious illness or complications like long covid, which is why protection matters. Covid is still well worth avoiding, even though so many people are not taking any precautions against catching covid these days. Research shows catching covid multiple times leaves people at twice more risk of dying from any cause, and three times as likely to be hospitalised in the following six months, than those who have only had covid once
The BA.5 and .5 omicron subvariants are more transmissible and better at avoiding our immune systems than previous variants. They’re creating huge waves in many countries, mostly thanks to the mutations that let them swerve our immune defences. Covid is affecting more vaccinated people, and infecting more people who’ve already been infected very recently.
So what can you do to avoid these ultra-infectious variants? This is what the experts recommend:
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