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Countries like Australia, which did incredibly well at battling the spread of the original variants, are struggling to control Omicron, and their health systems are already creaking under the weight of thousands of new cases. Most of those who are being hospitalised with Omicron are either unvaccinated or otherwise vulnerable. So far we know Omicron is more infectious but less severe. So what’s going on? Here are the facts about the latest variant to sweep the world.
More infectious but less deadly
The global number of confirmed covid cases is at a record high at the moment thanks to Omicron. The variant displays 50 or so mutations compared to the original, and it’s a lot more infectious than all previous variants. At the same time we’re seeing a lower proportion of hospitalisations and deaths.
One reason Omicron is less severe is the sheer number of people whose jabs and previous infections are protecting them against serious disease. Another seems to be that the variant is ‘inherently less likely’ to cause dangerous symptoms. And a much higher proportion of people are asymptomatic, spreading the virus without realising they’ve been infected.
Is Omicron inherently less dangerous?
Animal research supports the ‘inherently less dangerous’ theory. A piece of research by a team at the University of Liverpool revealed mice became less ill and recovered faster from Omicron. The results of other early animal studies seem to agree. The reason is the variant infects cells slightly differently.
Omicron’s weird spike protein action
Usually, the covid spike protein attaches itself to a protein called ACE2, which sticks out of most human cells. The spike protein gets cut by another protein, TMPRSS2, which forces the virus to release its contents into the cell.
Omicron is different because the spike protein doesn’t get cut outside the human cell. The virus first becomes enveloped inside the cell’s membrane before being ‘pinched off’ into a little container inside the cell. Then the spike protein gets cut by proteins, this time called cathepsins. The whole process takes more time and is uncannily similar to the way SARS infects people, just less deadly.
What does this mean for people who catch omicron?
The results of this and many other tests reveal Omicron is more likely to infect the nose than the lungs, effectively morphing the original covid variant from an infection of the lower respiratory tract to one of the upper respiratory tract. As a result higher levels of virus in saliva means Omicron spreads unusually fast when people talk, shout, cough or sing.
What about future variants?
We have no idea why Omicron has turned out this way. One thing, though, is clear. There’s no guarantee that future variants will be less dangerous. Sadly, viruses don’t work that way.
Scientists are busy finding out more about omicron
All these early findings about Omicron are ‘preliminary and need to be confirmed’. Scientists are still appealing to people and governments to ‘tread cautiously’ in their ‘interpretations of everything.’
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