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There’s important work going on to help deal with viruses in future, and it might be able to warn us about the risk of nasty outbreaks. The science involves routinely sequencing the genes of viruses like flu and RSV, which give humans serious respiratory infections, in an effort to invent more effective medicines and vaccines. Doing so might even make it easier to track potentially dangerous outbreaks in future.
Welcome to the Respiratory Virus and Microbiome Initiative, led by Ewan Harrison at the Wellcome Sanger Institute in Cambridge. Here’s the low-down.
What the science involves
The plan is to collect samples of virus from people suffering nasty respiratory infections and sequence the viral DNA. The new tech is due to be tested later in 2023, with the intention to roll it out through 2024. So far the UK team is the only one planning the work but they hope the rest of the world will join in, which is why they’re making the methods and data freely available to anyone who wants it.
This is how we discover variants
Covid saw many countries routinely sequencing many thousands of samples, essential to pin down what the virus was up to. This is how scientists discovered the omicron variants, accurately predicting they’d spread fast around the world. For the first time, governments and policymakers were warned about the likely development of an epidemic. The project builds on this essential work.
Finding out exactly what makes these viruses tick
It’s strange but true – we still know very little about the viruses that cause humans such serious respiratory issues. There’s been a small amount of work on flu virus genome sequencing but it isn’t routine and other viruses are more or less a mystery. Current testing only reveals the kind of virus it is, for example a rhinovirus or adenovirus.
To know more about a virus we need to sequence its entire genome. Once we do that we’ll know more about the most effective treatments and will be able to make better vaccines. We’ve already seen it in action informing the updating of crucial mRNA booster shots.
Because sequencing viral genes reveals how they spread, the insight should be vital for containing the spread of viruses. The work is also predicted to help us spot new emerging diseases early, something we’ll struggle with without routine genomic surveillance.
The technology and methods developed by the team will be ‘extremely useful’ according to Judith Breuer, a virologist at University College London, who told New Scientist magazine, “This is an amazingly important initiative.”
In the meantime, here’s how to kill viruses fast, affordably, and efficiently
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